Logical design of an anti‐cancer agent targeting the plant homeodomain in Pygopus2
نویسندگان
چکیده
منابع مشابه
Logical design of an anti‐cancer agent targeting the plant homeodomain in Pygopus2
Pygopus2 (Pygo2) is a component of the Wnt signaling pathway, which is required for β-catenin mediated transcription. Plant homeodomain (PHD) finger in Pygo2 intercalates the methylated histone 3 (H3K4me) tail and HD1 domain of BCL9 that binds to β-catenin. Thus, PHD finger may be a potential target for the logical design of an anti-cancer drug. Here, we found that Spiro[2H-naphthol[1,2-b]pyran...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2016
ISSN: 1347-9032,1349-7006
DOI: 10.1111/cas.12995